Basic Information
| LncRNA/CircRNA Name | SOX2OT |
| Synonyms | SOX2-OT, NCRNA00043, SOX2OT |
| Region | GRCh38_3:180989762-181836880 |
| Ensemble | ENSG00000242808 |
| Refseq | NR_004053 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic ductal adenocarcinoma |
| ICD-0-3 | C25.3 |
| Methods | qRT-PCR, RIP, western blotting |
| Sample | pancreatic ductal adenocarcinoma (PDAC) cell lines MIA PaCa-2 (RRID:CVCL_0428), PANC-1 (RRID:CVCL_0480), CFPAC-1 (RRID:CVCL_1119), BxPC-3 (RRID:CVCL_0186) and the normal pancreatic ductal epithelial cell shTERT-HPNE (RRID:CVCL_C466),pancreatic tissue specimens |
| Expression Pattern | up-regulated |
| Function Description | SOX2OT was confirmed to promote the proliferation of PDAC cells. It was found to directly physically bind to FUS and we also demonstrated that FUS protein stability was affected by binding with SOX2OT and FUS could suppressed PDAC tumor by regulating cell cycle-associated factors CCND1 and p27. Our findings suggest that SOX2OT may act as a tumor promoter in PDAC through physically binding FUS and regulating its downstream cell cycle-associated factors CCND1 and p27. |
| Pubmed ID | 31837005 |
| Year | 2020 |
| Title | Long Noncoding RNA SOX2OT Promotes the Proliferation of Pancreatic Cancer by Binding to FUS |
External Links
| Links for SOX2OT | GenBank HGNC NONCODE |
| Links for pancreatic ductal adenocarcinoma | OMIM COSMIC |