Basic Information
| LncRNA/CircRNA Name | SOX2OT |
| Synonyms | SOX2-OT, NCRNA00043, SOX2OT |
| Region | GRCh38_3:180989762-181836880 |
| Ensemble | ENSG00000242808 |
| Refseq | NR_004053 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR |
| Sample | Blood specimens |
| Expression Pattern | up-regulated |
| Function Description | CCAT1 and SOX2OT could be detected in peripheral blood, showing different expression levels between NSCLC patients and cancer-free controls. It was demonstrated that CCAT1 and SOX2O complied with key characteristics of diagnostic biomarkers, being minimally-invasive, exhibiting high specificity, and robustness. Moreover, the combination of CCAT1 and SOX2OT had a higher positive diagnostic rate of NSCLC than CCAT1 or SOX3OT alone. |
| Pubmed ID | 31933793 |
| Year | 2019 |
| Title | Combined Identification of LncRNA CCAT1 and SOX3OT in Serum as an Effective Screening for Non-Small Cell Lung Cancer |
External Links
| Links for SOX2OT | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |