Basic Information
| LncRNA/CircRNA Name | SOX21-AS1 |
| Synonyms | NA |
| Region | GRCh38_13:94712716-94716246 |
| Ensemble | ENSG00000227640 |
| Refseq | NR_046514 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | oral squamous cell carcinoma |
| ICD-0-3 | C06.9 |
| Methods | qPCR, Cell migration and invasion assay, In vitro methylation etc. |
| Sample | OSCC tissues, cell lines (SAS and CAL27) |
| Expression Pattern | down-regulated |
| Function Description | The expression levels of SOX21-AS1 significantly decreased in OSCC compared with the adjacent normal tissue. The promoter activity of SOX21-AS1 was obviously suppressed by in vitro methylation. The DNA methylation status of the SOX21-AS1 promoter was analyzed using combined bisulfite restriction analysis, revealing that the aberrant promoter hypermethylation of SOX21-AS1 was observed frequently in OSCC tissues. Our data showed that SOX21-AS1 could significantly suppress oral cancer cell growth and invasion. |
| Pubmed ID | 27933111 |
| Year | 2016 |
| Title | Aberrant DNA hypermethylation-silenced SOX21-AS1 gene expression and its clinical importance in oral cancer. |
External Links
| Links for SOX21-AS1 | GenBank HGNC NONCODE |
| Links for oral squamous cell carcinoma | OMIM COSMIC |