Basic Information
| LncRNA/CircRNA Name | SOX21-AS1 |
| Synonyms | NA |
| Region | GRCh38_13:94712716-94716246 |
| Ensemble | ENSG00000227640 |
| Refseq | NR_046514 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Luciferase reporter assay, RIP |
| Sample | colorectal cancer tissues, cell lines (HT29, HCT8, LS513, SW620 and HCT116,FHC) |
| Expression Pattern | up-regulated |
| Function Description | lncRNA SOX21-AS1 expression was significantly over-expressed in CRC tissue samples and cells. The aberrant over-expression of SOX21-AS1 indicated poor prognosis of CRC patients. SOX21-AS1 silencing inhibited the proliferation, invasion, and decreased the tumor growth of CRC cells.miR-145 was proved to be the target of SOX21-AS1,besides, myosin VI (MYO6) was found to be one of the targets of miR-145.the tumorigenic effect of lncRNA SOX21-AS1 in CRC cells via targeting miR-145/MYO6, providing a novel insight for CRC carcinogenesis. |
| Pubmed ID | 29217166 |
| Year | 2017 |
| Title | Long non-coding RNA SOX21-AS1 sponges miR-145 to promote the tumorigenesis of colorectal cancer by targeting MYO6. |
External Links
| Links for SOX21-AS1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |