Basic Information
| LncRNA/CircRNA Name | SOCAR |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Western blot |
| Sample | The human epithelial OvCa cell lines SKOV3, OVCAR3, CAOV3, and HO-8910PM, Primary OvCa tissues (POCTs) and paired omental metastasis tissues (OMTs) |
| Expression Pattern | up-regulated |
| Function Description | A novel serous OvCa-related lncRNA, SOCAR, was identified via microarray. SOCAR was overexpressed in primary HGSOC tumors compared with normal ovary tissues, and the expression of SOCAR correlated with progression in HGSOC patients. SOCAR also had higher expression in metastatic HGSOC tissues compared with primary cancer tissues. Moreover, upregulation of SOCAR promoted proliferation, migration and invasion in OvCa cells. Expression of Wnt1, ?-catenin and MMP-9 were all increased by SOCAR overexpression |
| Pubmed ID | 31299360 |
| Year | 2019 |
| Title | The clinical significance and biological function of lncRNA SOCAR in serous ovarian carcinoma |
External Links
| Links for SOCAR | GenBank HGNC NONCODE |
| Links for Ovarian cancer | OMIM COSMIC |