Basic Information
| LncRNA/CircRNA Name | SNHG8 |
| Synonyms | SNHG8, LINC00060, NCRNA00060 |
| Region | GRCh38_4:118278709-118279823 |
| Ensemble | ENSG00000269893 |
| Refseq | NR_003584 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | endometrial cancer |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | cell line (Ishikawa, Japan, HEC1-A, HEC1-B, AN3CA, RL95-2), EC tissue |
| Expression Pattern | up-regulated |
| Function Description | SNHG8 expression in endometrial carcinoma tissue was significantly higher than that in normal endometrium.After transfection with SNHG8 siRNA,the cell viability of AN3CA cells decreased, whereas the activity of Ishikawa was increased after transfection with SNHG8 overexpression plasmid.SNHG8 was bound to miR-152 and miR-152 targeted on c-MET. In addition, miR-152 mimics inhibited the expression of c-MET, and the inhibitory effect was reversed after SNHG8 overexpression. Silencing SNHG8 reduced c-MET expression, and c-MET expression was reversed after addition of miR-152 inhibitor. |
| Pubmed ID | 29630089 |
| Year | 2018 |
| Title | LncRNA SNHG8 participates in the development of endometrial carcinoma through regulating c-MET expression by miR-152 |
External Links
| Links for SNHG8 | GenBank HGNC NONCODE |
| Links for endometrial cancer | OMIM COSMIC |