Basic Information
| LncRNA/CircRNA Name | SNHG8 |
| Synonyms | SNHG8, LINC00060, NCRNA00060 |
| Region | GRCh38_4:118278709-118279823 |
| Ensemble | ENSG00000269893 |
| Refseq | NR_003584 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RNAi, other |
| Sample | NSCLC tissues and cell lines (A549, H23, SPC-A1, and NCI-H292) |
| Expression Pattern | up-regulated |
| Function Description | SNHG8 was over-expressed in NSCLC tissues and cells. Patients with high SNHG8 expression have poorer overall survival (OS) and progression-free survival (PFS) than the patients with low SNHG8 expression. SNHG8 knockdown inhibited NSCLC cell proliferation in vitro and in vivo, arrested cell cycle in the G0/G1 phase via targeting miR-542-3p/CCND1/ CDK6, and induced cell apoptosis via activation of Caspase-3. |
| Pubmed ID | 30275712 |
| Year | 2018 |
| Title | SNHG8 Is Identified as a Key Regulator in Non-Small-Cell Lung Cancer Progression Sponging to miR-542-3p by Targeting CCND1/CDK6 |
External Links
| Links for SNHG8 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |