Basic Information
| LncRNA/CircRNA Name | SNHG8 |
| Synonyms | small nucleolar RNA host gene 8 |
| Region | GRCh38_4:118278709-118279823 |
| Ensemble | ENSG00000269893 |
| Refseq | NR_003584 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qRT-PCR, Western blot assay, RIP |
| Sample | cell lines containing HeLa (HPV18-positive), SiHa (HPV 16-positive), MS751 cells (HPV45-positive), CaSki (HPV16-positive) andHPV-negative cell line C33A |
| Expression Pattern | up-regulated |
| Function Description | SNHG8 displayed a crucial role in accelerating HPV-positive CC cell proliferation and migration.SNHG8 was mainly distributed in the nucleus and impaired RECK expression in HPV-positive CC cells.SNHG8 depletion decreased RECK transcription through EZH2-dependent manner.SNHG8 contributed to malignant phenotypes of HPV-positive CC cells via inhibiting RECK transcription in an EZH2-dependent manner. |
| Pubmed ID | 31961005 |
| Year | 2020 |
| Title | LncRNASNHG8acceleratesproliferationandinhibits apoptosisinHPV-inducedcervicalcancerthrough recruitingEZH2toepigeneticallysilenceRECKexpression |
External Links
| Links for SNHG8 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |