Basic Information
| LncRNA/CircRNA Name | SNHG7 |
| Synonyms | NA |
| Region | GRCh38_9:136721366-136728184 |
| Ensemble | ENSG00000233016 |
| Refseq | NR_003672 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Luciferase reporter assay |
| Sample | human breast cancer cell lines (ZR-75-1, HCC-1973, MDA-MB-231, and MDA-MB-468), normal breast epithelial cell line MCF-10A, breast cancer tissues and adjacent normal tissues |
| Expression Pattern | up-regulated |
| Function Description | SNHG7 was found to be significantly upregulated in breast cancer tissues when compared with normal tissues. Breast cancer cell lines showed higher levels of SNHG7 than normal breast epithelial cell line. The knockdown of SNHG7 by siRNA could remarkably repress breast cancer cell proliferation and invasion. Moreover, miRNA-381 was newly confirmed as a direct target of SNHG7 and it mediated the suppressing effects of SNHG7 on breast cancer cells. |
| Pubmed ID | 31378900 |
| Year | 2019 |
| Title | Long non-coding RNA (lncRNA) small nucleolar RNA host gene 7 (SNHG7) promotes breast cancer progression by sponging miRNA-381 |
External Links
| Links for SNHG7 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |