Basic Information
| LncRNA/CircRNA Name | SNHG7 |
| Synonyms | NA |
| Region | GRCh38_9:136721366-136728184 |
| Ensemble | ENSG00000233016 |
| Refseq | NR_003672 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatic carcinoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, etc. |
| Sample | hepatic carcinoma tissues, HepG2 and HCC-LM3 cell lines |
| Expression Pattern | up-regulated |
| Function Description | SNHG7 expression was significantly upregulated in hepatic carcinoma tissues, especially in aggressive cases, and it was closely correlated with the poor prognosis. Furthermore, knockdown of SNHG7 inhibited the proliferation, migration, and invasion of hepatic carcinoma cell lines in vitro. Mechanistically, SNHG7 directly interacted with miR 425 as a ceRNA. Moreover, knockdown of SNHG7 significantly inhibited the tumorigenic Wnt/? catenin/EMT pathway. SNHG7 regulated Wnt/? catenin/EMT pathway through sponging miR 425 and played an oncogenic role in hepatic carcinoma progression. |
| Pubmed ID | 31478234 |
| Year | 2019 |
| Title | lncRNA SNHG7 sponges miR-425 to promote proliferation, migration, and invasion of hepatic carcinoma cells via Wnt/?-catenin/EMT signalling pathway |
External Links
| Links for SNHG7 | GenBank HGNC NONCODE |
| Links for hepatic carcinoma | OMIM COSMIC |