Basic Information
| LncRNA/CircRNA Name | SNHG7 |
| Synonyms | NA |
| Region | GRCh38_9:136721366-136728184 |
| Ensemble | ENSG00000233016 |
| Refseq | NR_003672 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | RT-qPCR, Western blot analysis, Dual luciferase reporter gene assay |
| Sample | cancer tissue,NPC cells (CNE1, HONE1, C666-1, and CNE2),normal nasopharyngeal epithelial cell line NP69 |
| Expression Pattern | up-regulated |
| Function Description | downregulated SNHG7 restricts GLI3 expression by upregulating miR-140-5p, which further suppresses cell proliferation, and promotes apoptosis of NPC.SNHG7 silencing and miR-140-5p elevation declined the drug resistance of drug-resistant NPC cells and their parent cells, restrained NPC cell colony formation ability and proliferation, and boosted cell apoptosis. |
| Pubmed ID | 31944163 |
| Year | 2020 |
| Title | Downregulated Long Non-Coding RNA SNHG7 Restricts Proliferation and Boosts Apoptosis of Nasopharyngeal Carcinoma Cells by Elevating microRNA-140-5p to Suppress GLI3 Expression |
External Links
| Links for SNHG7 | GenBank HGNC NONCODE |
| Links for nasopharyngeal cancer | OMIM COSMIC |