Basic Information
| LncRNA/CircRNA Name | SNHG7 |
| Synonyms | NA |
| Region | GRCh38_9:136721366-136728184 |
| Ensemble | ENSG00000233016 |
| Refseq | NR_003672 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP etc |
| Sample | CC cell lines (C-33A, CaSki, SiHa, HeLa) |
| Expression Pattern | up-regulated |
| Function Description | SNHG7 was conspicuously higher expressed in CC cells. Knockdown of SNHG7 was detected to ameliorate the malignant behaviors of CC cells. Importantly, the contribution of SNHG7 to CC development was relied on activated Wnt pathway through DDK1-mediated manner. Furthermore, it was confirmed that SNHG7 silencing weakened the binding of EZH2 to DKK1 promoter as well as the occupancy of H3K27me3 in DKK1 promoter. |
| Pubmed ID | 32275170 |
| Year | 2020 |
| Title | Long Noncoding RNA SNHG7 Activates Wnt/?-Catenin Signaling Pathway in Cervical Cancer Cells by Epigenetically Silencing DKK1 |
External Links
| Links for SNHG7 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |