Basic Information
| LncRNA/CircRNA Name | SNHG6 |
| Synonyms | SNHG6, HBII-276HG, NCRNA00058, U87HG |
| Region | GRCh38_8:66921684-66926398 |
| Ensemble | ENSG00000245910 |
| Refseq | NR_002599 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioblastoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot etc. |
| Sample | glioblastoma tissue, cell lines (U87, U251, SHG44, U373-MG) |
| Expression Pattern | up-regulated |
| Function Description | In this study, the high expression of SNHG6 was tested in both glioma tissues and glioma cells. The correlation between expression levels of SNHG6 and the overall survival of glioma patients was demonstrated by using Kaplan Meier method analysis. Next, gain of function assays revealed that overexpression of SNHG6 can promote the formation of malignant phenotype of 1800 cell. However, results of loss-of-function assays revealed that silenced SNHG6 exerted the inhibitory function on glioma cell growth. Flow cytometric analysis was performed in glioma cells to detect the anti-oncogenic effects of silenced SNHG6 on cell cycle and apoptosis. Finally, we identified that p21 was involved in glioma cell proliferation after SNHG6 was downregulated. |
| Pubmed ID | 29579705 |
| Year | 2018 |
| Title | LncRNA SNHG6 acts as a prognostic factor to regulate cell proliferation in glioma through targeting p21. |
External Links
| Links for SNHG6 | GenBank HGNC NONCODE |
| Links for glioblastoma | OMIM COSMIC |