Basic Information
| LncRNA/CircRNA Name | SNHG6 |
| Synonyms | SNHG6, HBII-276HG, NCRNA00058, U87HG |
| Region | GRCh38_8:66921684-66926398 |
| Ensemble | ENSG00000245910 |
| Refseq | NR_002599 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot etc. |
| Sample | gastric tumor tissue, cell lines (MGC-803, AGS, SGC-7901, BGC-823) |
| Expression Pattern | up-regulated |
| Function Description | SNHG6 was overexpressed in gastric cancer tissues and cell lines.In summary,our findings demonstrated that SNHG6 acted as an oncogene in gastric cancer cells through regulating miR-101-3p/ZEB1 at a post-transcriptional level and silencing expression at a transcriptional level by recruiting enhancer of zeste homolog 2 (EZH2) to the promoter of p27. High expression levels of SNHG6 wereassociated with invasion depth, lymph node metastasis, distant metastasis and tumor/node/metastasis (TNM) stage, and predicted poor prognosis. |
| Pubmed ID | 28683446 |
| Year | 2017 |
| Title | LncRNA SNHG6 is Associated with Poor Prognosis of Gastric Cancer and Promotes Cell Proliferation and EMT through Epigenetically Silencing p27 and Sponging miR-101-3p |
External Links
| Links for SNHG6 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |