Basic Information
| LncRNA/CircRNA Name | SNHG6 |
| Synonyms | SNHG6, HBII-276HG, NCRNA00058, U87HG |
| Region | GRCh38_8:66921684-66926398 |
| Ensemble | ENSG00000245910 |
| Refseq | NR_002599 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | tongue cancer |
| ICD-0-3 | C02 |
| Methods | qPCR, Western blot, other |
| Sample | TC tissues and cell line(Tca8113) |
| Expression Pattern | up-regulated |
| Function Description | Compared to normal tissue or normal tongue epithelial cells, SNHG6 expression levels increased significantly in tongue cancer tissue or Tca1183 cells. SNHG6 expression in tongue cancer tissue was not correlated with age and gender, but with tissue differentiation degree, clinical stage and lymph node metastasis. Knockdown of SNHG6 in Tca1183 cells significantly inhibited the cell viability and proliferation and induced apoptosis. Furthermore, knockdown of SNHG6 significantly inhibited the EMT of Tca1183 cells by inducing the ?-catenin and E-cadherin protein expression and inhibiting N-cadherin and vimentin protein expression. Conclusion SNHG6 expression is significantly increased in tongue cancer, and the interference of SNHG6 expression can inhibit the proliferation and EMT of tongue cancer cells. |
| Pubmed ID | 30463652 |
| Year | 2018 |
| Title | Knockdown of lncRNA SNHG6 Inhibites the Proliferation and Epithelial Mesenchymal Transition in Tongue Cancer Cells |
External Links
| Links for SNHG6 | GenBank HGNC NONCODE |
| Links for tongue cancer | OMIM COSMIC |