Basic Information
| LncRNA/CircRNA Name | SNHG6 |
| Synonyms | NA |
| Region | GRCh38_8:66921684-66926398 |
| Ensemble | ENSG00000245910 |
| Refseq | NR_002599 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy/apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | osteosarcoma tumor tissues and adjacent normal tissues ,human normal osteoblastic cell line hFOB, human osteosarcoma cell lines(SOSP-9607 and MG63 cells) |
| Expression Pattern | up-regulated |
| Function Description | SNHG6 as a lncRNAs that significantly up-regulated in OS tissues and cells, patients with high SNHG6 expression suffered more malignant metastasis and shorter survival times.Furthermore, silencing of SNHG6 in OS significantly inhibited OS cell growth, weakened cell invasion capacity, arrested cell cycle at G0/G1 phase, and induced cell apoptosis.SNHG6 could competitively sponging miR-26a-5p thereby regulating ULK1, and induced cell apoptosis and autophagy by targeting caspase3 and ATF3. |
| Pubmed ID | 30988663 |
| Year | 2019 |
| Title | Silencing of SNHG6 Induced Cell Autophagy by Targeting miR-26a-5p/ULK1 Signaling Pathway in Human Osteosarcoma |
External Links
| Links for SNHG6 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |