Basic Information
| LncRNA/CircRNA Name | SNHG6 |
| Synonyms | NA |
| Region | GRCh38_8:66921684-66926398 |
| Ensemble | ENSG00000245910 |
| Refseq | NR_002599 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian clear cell carcinoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | ovarian clear cell carcinoma tissues ,normal ovarian tissues ,cell lines(HEK-293T and ES-2 ,RMG-1, TOV21G, OVCA420 and OVISE) |
| Expression Pattern | up-regulated |
| Function Description | SNHG6 expression was abnormally up-regulated in OCCC tissues relative to that in unpaired normal ovarian tissues.High SNHG6 expression was correlated with vascular invasion, distant metastasis and poor survival.Knockdown of SNHG6 in OCCC cells inhibited cell proliferation, migration and invasion in vitro as well as tumour growth in vivo.Moreover, SNHG6 functioned as a competing endogenous RNA (ceRNA), effectively acting as a sponge for miR-4465 and thereby modulating the expression of enhancer of zeste homolog 2 (EZH2). |
| Pubmed ID | 31119871 |
| Year | 2019 |
| Title | Long Non-Coding RNA SNHG6 Promotes Cell Proliferation and Migration Through Sponging miR-4465 in Ovarian Clear Cell Carcinoma |
External Links
| Links for SNHG6 | GenBank HGNC NONCODE |
| Links for ovarian clear cell carcinoma | OMIM COSMIC |