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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	Breast Cancer
ICD-0-3	C50
Methods	qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP
Sample	MCF10A, MCF7, T47D, BT474, BT549, MDA-MB-468, andMDAMB231 cell lines, breast cancer tissue and paired adjacent normal breast tissue
Expression Pattern	up-regulated
Function Description	small nucleolar RNA host gene 5 (SNHG5) promotes breast cancer cell proliferation both in vitro and in vivo, and depletion of SNHG5 significantly led to cell-cycle arrest at G1 phase. Accumulating evidence has shown that many lncRNA transcripts could function as competing endogenous RNAs (ceRNAs) by competitively binding common microRNAs (miRNAs). We found that SNHG5 acts as a sponge for miR-154-5p, reducing its ability to repress proliferating cell nuclear antigen (PCNA). SNHG5 promoted breast cancer proliferation and cell-cycle progression by upregulation of PCNA expression. Clinically, we observed an increased SNHG5 expression in breast cancer, whereas miR-154-5p was decreased in breast cancer tissues compared with the adjacent normal breast tissues. Furthermore, the SNHG5 expression was significantly negatively correlated with miR-154-5p expression.
Pubmed ID	31255976
Year	2019
Title	SNHG5 Promotes Breast Cancer Proliferation by Sponging the miR-154-5p/PCNA Axis

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