Basic Information
| LncRNA/CircRNA Name | SNHG5 |
| Synonyms | SNHG5, C6orf160, LINC00044, NCRNA00044, U50HG, bA33E24.2 |
| Region | GRCh38_6:85660950-85678736 |
| Ensemble | ENSG00000203875 |
| Refseq | NR_003038 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | Microarray, qPCR, Western blot, Luciferase reporter assay, other |
| Sample | CRC tissues and cell lines(RKO, SW480, LoVo) |
| Expression Pattern | up-regulated |
| Function Description | Overexpression of SNHG5 and CREB5 resulted in the enhancement of proliferation, metastasis, migration and the inhibition of apoptosis in CRC cells, while miR-132-3p led to the opposite result. LncRNA SNHG5 promoted proliferation, migration and metastasis of CRC cells but inhibited apoptosis by modulating miR-132-3p/CERB5. |
| Pubmed ID | 30395767 |
| Year | 2019 |
| Title | LncRNA SNHG5 affects cell proliferation, metastasis and migration of colorectal cancer through regulating miR-132-3p/CREB5. |
External Links
| Links for SNHG5 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |