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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	lung cancer
ICD-0-3	C34
Methods	qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RNAi
Sample	NCI-H2170, NCI-H520 and SK-MES-1 are human squamous carcinoma cell lines, NCI-H1975, NCI-H1437 and SPC-A-1 are human adenocarcinoma cell lines. , tumor tissues
Expression Pattern	up-regulated
Function Description	We observed a significantly inhibited cell proliferation in vitro and reduced 30 tumor growth in vivo after SNHG4 silencing. SNHG4 knockdown also led to cell cycle 31 arrest at G1 phase, accompanied with down-regulation of cyclin-dependent kinases 32 CDK4 and CDK6. Migration and invasion of these two cell lines were remarkably 33 inhibited after SNHG4 silencing. Moreover, our study revealed that epithelial34 mesenchymal transition (EMT) of lung cancer cells was suppressed by SNHG4 35 silencing as evidenced by up-regulated E-cadherin and down-regulated SALL4, Twist 36 and vimentin. In addition, we found that SNHG4 silencing induced elevation in miR37 98-5p. MiR-98-5p inhibition abrogated the effect of SNHG4 silencing on proliferation 38 and invasion of lung cancer cells.
Pubmed ID	31220419
Year	2019
Title	LncRNA SNHG4 promotes proliferation, migration, invasion and 2 epithelial-mesenchymal transition of lung cancer cells by regulating 3 miR-98-5p

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