Basic Information
| LncRNA/CircRNA Name | SNHG4 |
| Synonyms | NA |
| Region | GRCh38_5:139274102-139283477 |
| Ensemble | ENSG00000281398 |
| Refseq | NR_003141 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | PC and corresponding normal tissues ,PC cells (PC-3, LNCaP, DU145, and 22RV1) and control cells ,WPMY-1 |
| Expression Pattern | up-regulated |
| Function Description | SNHG4 was highly expressed in PCa and its upregulation was induced by transcription factor SP1.The high levels of SNHG4 were distinctly associated with tumor stage, lymph node metastasis, and reduced overall survival of patients with PCa.SNHG4 knockdown inhibited the growth, migration, and invasion of PCa cells. In addition, miR-377 was a target of SNHG4 and ZIC5 was a target gene of miR-377 in PCa. SNHG4 promoted ZIC5-mediated growth and metastasis through modulating miR-377. |
| Pubmed ID | 31608997 |
| Year | 2019 |
| Title | SP1-mediated Upregulation of lncRNA SNHG4 Functions as a ceRNA for miR-377 to Facilitate Prostate Cancer Progression Through Regulation of ZIC5 |
External Links
| Links for SNHG4 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |