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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis	apoptosis	Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	clear cell renal cell carcinoma
ICD-0-3	C64.9
Methods	qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, etc.
Sample	ccRCC tissue, renal cancer cell lines(ACHN, A498, Caki-1), immortalized renal tubular epithelial cell HK-2
Expression Pattern	up-regulated
Function Description	the expression of SNHG3 was increased in clear cell renal cell carcinoma (ccRCC), which was positively correlated with many clinicopathological parameters, and the higher expression of SNHG3 predicted worse clinical prognosis. Functional experiments indicated that knockdown of SNHG3 could significantly inhibit the proliferation and metastasis of ccRCC in vitro and in vivo. Subsequently, through luciferase reporter assays, qPCR and rescue experiments, it was found that SNHG3 could bind to miR-139-5p, thereby up-regulating the expression of its target gene TOP2A, and play a role in promoting tumor progression in ccRCC. The correlation analysis showed that there was a significant positive correlation between the expression of SNHG3 and TOP2A, and both of them were significantly negative correlated with the expression of miR-139-5p.
Pubmed ID	31505165
Year	2019
Title	LncRNA SNHG3 promotes clear cell renal cell carcinoma proliferation and migration by upregulating TOP2A

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