Basic Information
| LncRNA/CircRNA Name | SNHG3 |
| Synonyms | small nucleolar RNA host gene 3 |
| Region | GRCh38_1:28505980-28510892 |
| Ensemble | ENSG00000242125 |
| Refseq | NR_002909.1 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR, Western blot |
| Sample | cancerous tissue,HCC cell lines Hep3B and HepG2 and immortalized human liver cell line L-02 |
| Expression Pattern | up-regulated |
| Function Description | SNHG3 and BMI1 were upregulated in HCC, while miR-139-5p was downregulated. Knockdown of SNHG3 or BMI1 and overexpression of miR-139-5p could inhibit cell proliferation, migration, and invasion in HCC.The lncRNA SNHG3/miR-139-5p/BMI1 axis plays an important role in cell proliferation, migration, and invasion in HCC. |
| Pubmed ID | 31692508 |
| Year | 2019 |
| Title | LncSNHG3/miR-139-5p/BMI1 Axis Regulates Proliferation, Migration, and Invasion in Hepatocellular Carcinoma |
External Links
| Links for SNHG3 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |