Basic Information
| LncRNA/CircRNA Name | SNHG20 |
| Synonyms | NA |
| Region | GRCh38_17:77086716-77094990 |
| Ensemble | ENSG00000234912 |
| Refseq | NR_027058 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Luciferase reporter assay |
| Sample | Glioma cell lines including U87, U251, SHG44 and SW-38, normal cell NHA, glioma cancer tissues and matched adjacent normal tissues |
| Expression Pattern | up-regulated |
| Function Description | SNHG20 was overexpressed in glioma tissues and cell lines. Down-regulation of SNHG20 suppressed the proliferation, migration and induced apoptosis of glioma cells. Molecular studies uncovered that SNHG20 acted as a competing endogenous RNA (ceRNA) to sponge the expression of miR-4486. MiR4486 was down-regulated in glioma tissues and significantly inversely correlated with the expression of SNHG20. Restoration of miR-4486 remarkably attenuated the promotion effect of SNHG20 on the growth of glioma cells. Further study revealed that miR-4486 targeted the E3 ubiquitin ligase mouse double minute 2 (MDM2) and negatively regulated the expression of MDM2. Down-regulation of MDM2 by miR-4486 increased the abundance of p53 in glioma cells. |
| Pubmed ID | 31298384 |
| Year | 2019 |
| Title | LncRNA SNHG20 promoted the proliferation of glioma cells via sponging miR-4486 to regulate the MDM2-p53 pathway |
External Links
| Links for SNHG20 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |