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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	gastric cancer
ICD-0-3	C16
Methods	qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, etc.
Sample	GC tissues, Human GC cell lines including AGS, MKN-45, SGC7901, and BGC-823 cell lines and immortalized normal gastric epithelial cell line GES-1
Expression Pattern	up-regulated
Function Description	the lncRNA SNHG20 expression was significantly higher in GC tissues compared with adjacent normal tissues by quantitative real time PCR (qRT PCR) analysis. Higher lncRNA SNHG20 expression was highly associated with tumor size and lymphatic metastasis of patients. Patients with higher lncRNA SNHG20 expression predicted a short disease free survival (DFS) and overall survival (OS). Furthermore, lncRNA SNHG20 expression negatively associated with miR 495 3p expression and regulated miR 495 3p expression. Function assays confirmed that lncRNA SNHG20 knockdown using RNA interference suppressed cell proliferation and invasion of GC by negatively regulating miR 495 3p expression. Moreover, we demonstrated that lncRNA SNHG20 inhibited zinc finger protein X linked (ZFX) expression by negatively miR 495 3p expression in GC cells. In vivo, the current study also indicated that lncRNA SNHG20 knockdown reduced the tumor growth by downregulating ZFX expression.
Pubmed ID	30520073
Year	2018
Title	LncRNA SNHG20 contributes to cell proliferation and invasion by upregulating ZFX expression sponging miR 495 3p in gastric cancer

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