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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	oral squamous cell carcinoma
ICD-0-3	C06.9
Methods	qPCR, Western blot, etc.
Sample	Human OSCC tissue, human OSCC cell lines (SCC4, HN4 and SCC15) and the normal human oral keratinocyte (NHOK) cell line
Expression Pattern	up-regulated
Function Description	SNHG20 expression was significantly increased in OSCC tissue specimens, compared with in adjacent non tumor tissue specimens. The increased SNHG20 expression in OSCC tissue specimens was associated with tumor differentiation and Tumor Node Metastasis stage. Kaplan Meier analysis and log rank tests indicated that Higher SNHG20 expression predicted a poor overall survival (OS) rate in patients with OSCC. Multivariate Cox proportional hazards regression analysis demonstrated that increased SNHG20 expression was an independent predictor for the OS of patients with OSCC. Knockdown of SNHG20 expression in OSCC cells suppressed proliferation. The cell proliferation associated proteins proliferating cell nuclear antigen and Ki67 expression levels were reduced when SNHG20 was knocked down in OSCC cells; thus, the results indicated that SHNG20 may serve as a predictor and potential target for OSCC treatment.
Pubmed ID	30655853
Year	2019
Title	SNHG20 serves as a predictor for prognosis and promotes cell growth in oral squamous cell carcinoma

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