Basic Information
| LncRNA/CircRNA Name | SNHG20 |
| Synonyms | NA |
| Region | GRCh38_17:77086716-77094990 |
| Ensemble | ENSG00000234912 |
| Refseq | NR_027058 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP, etc. |
| Sample | Tumour tissues [HBV(+) HCC], Normal human liver cell line LO2, HBV(-) HCC cell line HepG2 and HBV(+) HCC cell line HepG2.2.15 |
| Expression Pattern | up-regulated |
| Function Description | SNHG20 was highly expressed in HBV(+) HCC cells than in HBV(-) HCC cells. SNHG20 expression level was positively associated with HBV x protein (HBx) in HCC cells, and HBxSNHG20 involved in regulating the proliferation and apoptosis of HCC cells. Moreover, SNHG20 was confirmed to interact with PTEN, which negatively regulated PTEN protein level. Finally, we proved HBxSNHG20PTEN signalling pathway involved in the regulation of HCC cell proliferation and apoptosis. In vivo experiments showed SNHG20 knockdown inhibited tumour growth of HBV(+) HCC. HBx promoted the proliferation of HCC cell and reduced the apoptosis of HCC cells through the SNHG20/PTEN signalling pathway. |
| Pubmed ID | 30690477 |
| Year | 2019 |
| Title | Hepatitis B virus x protein accelerated the proliferation of hepatocellular carcinoma cell through lncRNA SNHG20/PTEN pathway. |
External Links
| Links for SNHG20 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |