Basic Information
| LncRNA/CircRNA Name | SNHG18 |
| Synonyms | SNHG18 |
| Region | GRCh38_5:9546200-9550609 |
| Ensemble | ENSG00000250786 |
| Refseq | NR_045196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | Microarray, qPCR, RNAi, Western blot, ISH etc. |
| Sample | cell lines (M059K, M059J, U87 and U251) |
| Expression Pattern | up-regulated |
| Function Description | The expression of SNHG18 was remarkably upregulated in clinical glioma tissues compared with normal brain tissues. SNHG18 expression was associated with the clinical tumor grade and correlated negatively with isocitrate dehydrogenase 1 mutation. In addition, knockdown of SNHG18 with short hairpin RNA suppressed the radioresistance of glioma cells, and transgenic expression of SNHG18 had the opposite effect. |
| Pubmed ID | 27788958 |
| Year | 2016 |
| Title | Upregulation of Long Noncoding RNA Small Nucleolar RNA Host Gene 18 Promotes Radioresistance of Glioma by Repressing Semaphorin 5A. |
External Links
| Links for SNHG18 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |