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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis	apoptosis	Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	melanoma
ICD-0-3	NA
Methods	qRT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc.
Sample	melanoma tissues and matched normal tissues ,melanoma cell lines(A375, A865, CHL-1,SK-MEL-2) ,melanocyte cell line HEMa-LP ,HT144
Expression Pattern	up-regulated
Function Description	High expressions of SNHG17 were observed in both melanoma tissues and cells. Up-regulation of SNHG17 in melanoma patients was associated with lymph node metastasis and tumor stage. Patients with high SNHG17 expression had significantly shorter survival time. SNHG17 was also confirmed to be independently associated with overall survival of melanoma patients. The proliferation, migration, and invasion of melanoma cells were noticeably reduced by the down-regulation of SNHG17.The up-regulation of SNHG17 was induced by STAT3. We also found that knockdown of SNHG17 resulted in the remarkable diminution in the phosphorylation levels of PI3K and AKT, suggesting that the activity of the PI3K-AKT pathway was suppressed.
Pubmed ID	31599425
Year	2019
Title	STAT3-induced Upregulation of lncRNA SNHG17 Predicts a Poor Prognosis of Melanoma and Promotes Cell Proliferation and Metastasis Through Regulating PI3K-AKT Pathway

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