Basic Information
| LncRNA/CircRNA Name | SNHG16 |
| Synonyms | SNHG16, Nbla10727, Nbla12061, ncRAN |
| Region | GRCh38_17:76557766-76565348 |
| Ensemble | ENSG00000163597 |
| Refseq | NR_038108 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, RNAi, Western blot, RIP, Luciferase reporter assay etc. |
| Sample | breast cancer tissues, cell lines (MDA-MB-231, MCF-7, MDA-MB-468 and HEK293T) |
| Expression Pattern | up-regulated |
| Function Description | Expression levels of SNHG16 were found to be frequently higher in breast cancer tissues than in the paired noncancerous tissues.Gain- and loss-of-function studies proved that SNHG16 significantly promoted breast cancer cell migration. In addition, we identified a positive correlation between SNHG16 and E2F5 in breast cancer tissues. Furthermore,we demonstrated that forced expression of miR-98 could partially abrogate SNHG16-mediated increase of breast cancer cells migration,suggesting that SNHG16 promoted cell migration in a miR-98 dependent manner. |
| Pubmed ID | 28232182 |
| Year | 2017 |
| Title | SNHG16 contributes to breast cancer cell migration by competitively binding miR-98 with E2F5. |
External Links
| Links for SNHG16 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |