Basic Information
| LncRNA/CircRNA Name | SNHG16 |
| Synonyms | SNHG16, Nbla10727, Nbla12061, ncRAN |
| Region | GRCh38_17:76557766-76565348 |
| Ensemble | ENSG00000163597 |
| Refseq | NR_038108 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP |
| Sample | cervical cancer tissues, Cervical cancer cell lines (HeLa, CaSki, SiHa, and C33A) |
| Expression Pattern | up-regulated |
| Function Description | miR-216-5p could interact with SNHG16 and there existed a negative correlation between the expression levels of miR-216-5p and SNHG16 in cervical cancer specimens. SNHG16 directly targeted miR-216-5p by harboring the binding sites of microRNA in the SNHG16 sequence.Additionally, bioinformatics analysis provided an evidence that ZEB1 was a potential target of miR-216-5p. |
| Pubmed ID | 29126969 |
| Year | 2017 |
| Title | SNHG16/miR-216-5p/ZEB1 signal pathway contributes to the tumorigenesis of cervical cancer cells. |
External Links
| Links for SNHG16 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |