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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis	apoptosis	Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	retinoblastoma
ICD-0-3	C69.2
Methods	qPCR, Luciferase reporter assay, in vitro knockdown, RIP
Sample	Human retinal epithelial cells ARPE-19 and two human RB cell lines WERI Rb1, SO-RB-50 and Y79, The human retinoblastoma cell line SO-Rb50, RB tissues and normal retinas
Expression Pattern	up-regulated
Function Description	SNHG16 expression was upregulated in RB tissues and cell lines compared with normal controls. Knockdown of SNHG16 in RB cells significantly inhibited the proliferation and colony formation, and promoted apoptosis in vitro, as well as retarded tumor growth in vivo. Mechanistic investigation illustrated that SNHG16 acted as a sponge for miR-140-5p and regulated its expression in RB cells. Clinical evidence revealed a negative correlation between SNHG16 and miR-140-5p in RB specimens. Rescue experiments showed that inhibition of miR-140-5p partially attenuated the growth-suppressing effects of SNHG16-depletion on RB cells..
Pubmed ID	31234025
Year	2019
Title	Long noncoding RNA SNHG16 promotes human retinoblastoma progression via sponging miR-140-5p

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