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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis	apoptosis	Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	papillary thyroid cancer
ICD-0-3	NA
Methods	qPCR, Luciferase reporter assay, in vitro knockdown, etc.
Sample	PTC tissues, PTC cell lines IHH-4, TPC-1, and HTH83,and normal thyroid follicular epithelial cell line Nthy-ori 3-1
Expression Pattern	up-regulated
Function Description	The SNHG16 expression was upregulated in PTC tissues and cell lines, whose expression was positively associated with advanced TNM stage and lymph node metastasis. Function analysis demonstrated that depletion of SNHG16 in PTC cells significantly inhibited cell proliferation, induced cell apoptosis, and suppressed cell migration and invasion abilities. Mechanistic studies indicated that SNHG16 functioned as an endogenous sponge for miR-497 to regulate its target genes brain-derived neurotrophic factor and yes-associated protein 1 expression. Furthermore, the inhibition of miR-497 antagonized the suppressive effect of SNHG16-depleted cells on cell proliferation, migration, and invasion. Conclusion: These findings revealed that SNHG16 drived the PTC progression possibly via regulating miR-497, suggesting that SNHG16 might be a novel therapeutic agent for PTC.
Pubmed ID	30705598
Year	2019
Title	LncRNA SNHG16 drives proliferation and invasion of papillary thyroid cancer through modulation of miR-497.

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