Basic Information
| LncRNA/CircRNA Name | SNHG16 |
| Synonyms | small nucleolar RNA host gene 16 |
| Region | GRCh38_17:76557766-76565348 |
| Ensemble | ENSG00000163597 |
| Refseq | NR_038108 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | Cisplatin | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR, Dual luciferase reporter assay, Western blot analysis, RIP |
| Sample | HCC tissue specimens,HCC lines (MHCC97H, HuH7, SMMC7721, Hep3B, and HepG2), one normal hepatocyte cell line (LO2), and HEK293 cells |
| Expression Pattern | up-regulated |
| Function Description | SNHG16 was highly expressed in HCC tissues and cell lines, which predicted poor prognosis of HCC patients.the downregulation of SNHG16 induced G2/M cell cycle arrest, inducing cell apoptosis and suppression of cell proliferation. On the other hand, it inhibited cell metastasis and EMT progression demonstrated by in vitro loss-of-function cell experiments. Besides, knockdown of SNHG16 increased the sensitivity of HCC cells to cisplatin.SNHG16 was demonstrated to act as a let-7b-5p sponge in HCC. |
| Pubmed ID | 31696971 |
| Year | 2020 |
| Title | SNHG16 as the miRNA let-7b-5p Sponge Facilitates the G2/M and Epithelial-Mesenchymal Transition by Regulating CDC25B and HMGA2 Expression in Hepatocellular Carcinoma |
External Links
| Links for SNHG16 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |