Basic Information
| LncRNA/CircRNA Name | SNHG16 |
| Synonyms | NA |
| Region | GRCh38_17:76557766-76565348 |
| Ensemble | ENSG00000163597 |
| Refseq | NR_038108 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | endometrial cancer |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Western blot, Dual luciferase reporter assay |
| Sample | endometrial carcinoma tissue samples,endometrial carcinoma cell lines (HEC-1B, HEC-1A, RL95-2, AN3CA) and normal endometrial cell line (EMC) |
| Expression Pattern | up-regulated |
| Function Description | SNHG16 expression was increased in the ECa tissue and cells, and the ectopic SNHG16 overexpression was closely correlated with the poor survival rate and recurrence free survival of ECa. As regarding the upstream, transcription factor TFAP2A bound with the promotor region of SNHG16 and activated its transcription.SNHG16 knockdown suppressed the proliferation, glycolysis and tumor growth of ECa cells. In mechanical experiments, SNHG16 upregulated HK2, the target gene of miR-490-3p, by competitively sponging miR-490-3p and then promoted endometrial carcinoma proliferation and glycolysis. |
| Pubmed ID | 31814916 |
| Year | 2019 |
| Title | LncRNA SNHG16 Induced by TFAP2A Modulates Glycolysis and Proliferation of Endometrial Carcinoma Through miR-490-3p/HK2 Axis |
External Links
| Links for SNHG16 | GenBank HGNC NONCODE |
| Links for endometrial cancer | OMIM COSMIC |