Basic Information
LncRNA/CircRNA Name | SNHG16 |
Synonyms | Small nucleolar RNA host gene 16 |
Region | GRCh38_17:76557766-76565348 |
Ensemble | ENSG00000163597 |
Refseq | NR_038108 |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | apoptosis | Drug | ||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | neuroblastoma |
ICD-0-3 | NA |
Methods | qRT-PCR, Western blot, Luciferase Reporter Assay, RIP |
Sample | NB patient tissues,NB cell lines (SK-N-SH, IMR-32, SK-N-AS and SK-NDZ) and human endothelial cell line (HUVEC) |
Expression Pattern | up-regulated |
Function Description | The levels of SNHG16 and HOXA7 were conspicuously increased in NB tissues and cells, while the expression of miR-128-3p was obviously declined, compared with corresponding normal tissues and cells. SNHG16 silencing inhibited proliferation, migration and invasion and induced apoptosis of NB cells. We identified that SNHG16 directly interacted with miR-128-3p, and miR-128-3p could target the 3'UTR of HOXA7 in NB cells. |
Pubmed ID | 31919621 |
Year | 2020 |
Title | SNHG16 Silencing Inhibits Neuroblastoma Progression by Downregulating HOXA7 via Sponging miR-128-3p |
External Links
Links for SNHG16 | GenBank HGNC NONCODE |
Links for neuroblastoma | OMIM COSMIC |