Basic Information
| LncRNA/CircRNA Name | SNHG16 |
| Synonyms | NA |
| Region | GRCh38_17:76557766-76565348 |
| Ensemble | ENSG00000163597 |
| Refseq | NR_038108 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP etc |
| Sample | cervical cancer tissues, cell lines (SiHa, CaSki, C33A, ME180, HeLa, HcerEpic) |
| Expression Pattern | up-regulated |
| Function Description | Here, quantitative analysis of SNHG16 and PARP9 expression levels in cervical cancer tissues and cell lines indicated that both SNHG16 and PARP9 were highly expressed compared with controls. Using the dual-luciferase reporter gene assay, RNA immunoprecipitation, chromatin immunoprecipitation, we were able to determine that SNHG16 recruited SPI1 protein to promote transcription of PARP9 to upregulate its transcription in cervical cancer cells. |
| Pubmed ID | 31774223 |
| Year | 2019 |
| Title | Long Noncoding RNA SNHG16 Promotes the Tumorigenicity of Cervical Cancer Cells by Recruiting Transcriptional Factor SPI1 to Upregulate PARP9 |
External Links
| Links for SNHG16 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |