Basic Information
| LncRNA/CircRNA Name | SNHG16 |
| Synonyms | NA |
| Region | GRCh38_17:76557766-76565348 |
| Ensemble | ENSG00000163597 |
| Refseq | NR_038108 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | 2 | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Luciferase reporter assay, RIP etc. |
| Sample | BC tissues and paired normal breast tissue,cell lines (MCF-10A, MCF-7, T-47D and MDA-MB-231,HEK293T) |
| Expression Pattern | up-regulated |
| Function Description | SNHG16 served as a ceRNA by sponging miR-16-5p, which led to the derepression of its target gene SMAD5 and resulted in potentiation of the TGF-?1/SMAD5 pathway to upregulate CD73 expression in V?1 T cells. Our results showed that the BC-derived exosomal SNHG16/miR-16-5p/SMAD5-regulatory axis potentiates TGF-?1/SMAD5 pathway activation, thus inducing CD73 expression in V?1 T cells. |
| Pubmed ID | 32345959 |
| Year | 2020 |
| Title | Breast cancer-derived exosomes transmit lncRNA SNHG16 to induce CD73+??1 Treg cells |
External Links
| Links for SNHG16 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |