Basic Information
| LncRNA/CircRNA Name | BZRAP1-AS1 |
| Synonyms | benzodiazapine receptor associated protein 1 antisense RNA 1 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | 2 | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | RT-qPCR, Western blot analysis, RIP, Dual luciferase reporter gene assay |
| Sample | HCC tissues,liver cells L-02 and human HCC cell lines (HuH-7, HCCLM3, LI7, BEL-7405, SK-HEP-1 and BCLC-9) |
| Expression Pattern | up-regulated |
| Function Description | BZRAP1-AS1 was identified as a highly expressed lncRNA in HCC tissues and cells. Down-regulation of BZRAP1-AS1 in HCC cells inhibited HUVEC proliferation, migration and angiogenesis. By interacting with DNMT3b, BZRAP1-AS1 induced methylation of the THBS1 promoter and inhibited the transcription of THBS1, resulting in promoted angiogenesis of HUVECs. Moreover, silencing of BZRAP1-AS1 repressed the angiogenesis as well as the tumor growth of HCC in vivo via up-regulating THBS1. |
| Pubmed ID | 31847842 |
| Year | 2019 |
| Title | Long Non-Coding RNA BZRAP1-AS1 Silencing Suppresses Tumor Angiogenesis in Hepatocellular Carcinoma by Mediating THBS1 Methylation |
External Links
| Links for BZRAP1-AS1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |