Basic Information
| LncRNA/CircRNA Name | SNHG15 |
| Synonyms | SNHG15, C7orf40, Linc-Myo1g, MYO1GUT |
| Region | GRCh38_7:44983023-44986961 |
| Ensemble | ENSG00000232956 |
| Refseq | NR_003697 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, RIP etc. |
| Sample | cell lines (hCMECs/D3) |
| Expression Pattern | up-regulated |
| Function Description | SNHG15 is highly expressed in glioma-induced endothelial cells while miR-153 is lowly expressed in glioma-induced endothelial cells.SNHG15 negatively regulates the expression of miR-153 and miR-153 negatively regulates the expression of VEGFA and Cdc42, which in turn affects glioma vascular endothelial cell proliferation, migration and tube formation in vitro. Therefore, we suggest that SNHG15 and miR-153 are novel targets for glioma anti-angiogenesis therapy. |
| Pubmed ID | 29048682 |
| Year | 2017 |
| Title | SNHG15 affects the growth of glioma microvascular endothelial cells by negatively regulating miR-153 |
External Links
| Links for SNHG15 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |