Basic Information
| LncRNA/CircRNA Name | SNHG15 |
| Synonyms | NA |
| Region | GRCh38_7:44983023-44986961 |
| Ensemble | ENSG00000232956 |
| Refseq | NR_003697 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, Luciferase reporter assay |
| Sample | HCC cell lines HuH-1, HuH-7 and normal human liver cells L-O2, HCC tissues and paired adjacent non-neoplastic liver tissues |
| Expression Pattern | up-regulated |
| Function Description | Our research showed that up-regulation of SNHG15 was found in HCC and was related to aggressive behaviors in HCC patients. Moreover, knockdown of SNHG15 restrained HCC cell proliferation, migration and invasion. In addition, SNHG15 served as a molecular sponge for miR-490-3p. Further, miR-490-3p directly targets HDAC2. HDAC2 was involved in HCC progression by interacting with the SNHG15/miR-490-3p axis. |
| Pubmed ID | 31636472 |
| Year | 2019 |
| Title | lncRNA-SNHG15 accelerates the development of hepatocellular carcinoma by targeting miR-490-3p/ histone deacetylase 2 axis |
External Links
| Links for SNHG15 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |