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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis	apoptosis	Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	non small cell lung cancer
ICD-0-3	C34
Methods	qPCR, Western blot, in vitro knockdown
Sample	non small cell lung cancer tissues, cell lines (PC9, SPC-A1, A549, H1703 and SK-MES-1)
Expression Pattern	up-regulated
Function Description	The expression of SNHG15 in cancer tissues was increased compared with that in para-carcinoma tissues. Kaplan-Meier survival analysis that the prognosis of patients in low SNHG15 expression group was significantly better than that in high SNHG15 expression group, and both disease-free survival (DFS) and overall survival (OS) were longer. Results of cell counting kit-8 (CCK-8) assay showed that knocking down SNHG15 could significantly inhibit the proliferation of lung cancer A549 cells. Hoechst 33342 staining and flow cytometry revealed that knocking down SNHG15 could significantly promote apoptosis of A549 cells. Wound healing assay and transwell assay revealed that knocking down SNHG15 could significantly inhibit the invasion and metastasis capacities of lung cancer A549 cells. Results of Western blotting showed that knocking down SNHG15 could inhibit the invasion and metastasis of A549 cells through inhibiting the expressions of epithelial-mesenchymal transition (EMT), matrix metalloproteinase-2 (MMP-2) and MMP-9 in cells.
Pubmed ID	29771418
Year	2018
Title	Long Non-Coding RNA SNHG15 Indicates Poor Prognosis of Non-Small Cell Lung Cancer and Promotes Cell Proliferation and Invasion

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