Basic Information
| LncRNA/CircRNA Name | SNHG14 |
| Synonyms | NA |
| Region | GRCh38_15:24978583-25419462 |
| Ensemble | ENSG00000224078 |
| Refseq | NR_146177 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | Cisplatin (CDDP) | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP |
| Sample | Human bronchial epithelioid cell line 16HBE and two NSCLC cell lines A549 (a human lung adenocarcinoma cell line derived from the respiratory epithelium) and H1299 (a NSCLC cell derived from metastatic lymph node site), NSCLC tissues and adjacent noncancerous tissues |
| Expression Pattern | up-regulated |
| Function Description | SNHG14 was upregulated in NSCLC cells, and SNHG14 silencing repressed the migration, invasion while accelerated the apoptosis of NSCLC cells. Moreover, we manifested that SNHG14 silencing promoted NSCLC cell sensitivity to CDDP. SNHG14 repressed miR-34a expression by binding to miR-34a. Additionally, SNHG14 regulated HMGB1 expression by sponging miR-34a. SNHG14 silencing exerted its regulatory effect by miR-34a and HMGB1 mediated the regulatory effect of miR-34a on NSCLC cells. |
| Pubmed ID | 31252267 |
| Year | 2019 |
| Title | SNHG14 silencing suppresses the progression and promotes cisplatin sensitivity in non small cell lung cancer |
External Links
| Links for SNHG14 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |