Basic Information
| LncRNA/CircRNA Name | SNHG14 |
| Synonyms | NA |
| Region | GRCh38_15:24978583-25419462 |
| Ensemble | ENSG00000224078 |
| Refseq | NR_146177 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qRT-PCR, Western blot analysis |
| Sample | ovarian cancer tissues,ovarian cancer cell lines (A2780, TOV112D, HO-8910, OVCAR-3, and SKOV3) and one normal ovarian cells (ISOE80) |
| Expression Pattern | up-regulated |
| Function Description | SNHG14 level was dramatically higher in ovarian cancer specimens. Moreover, cell migration and invasion were significantly attenuated via the inhibition of SNHG14, while enhanced via the SNHG14 overexpression. Besides, the expression of DGCR8 mRNA and protein was markedly downregulated after the knockdown of SNHG14, while upregulated after SNHG14 overexpression. |
| Pubmed ID | 31841176 |
| Year | 2019 |
| Title | Long Noncoding RNA SNHG14 Enhances Migration and Invasion of Ovarian Cancer by Upregulating DGCR8 |
External Links
| Links for SNHG14 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |