Basic Information
| LncRNA/CircRNA Name | SNHG14 |
| Synonyms | NA |
| Region | GRCh38_15:24978583-25419462 |
| Ensemble | ENSG00000224078 |
| Refseq | NR_146177 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | RT-qPCR, Luciferase Reporter Gene Assay, RIP |
| Sample | Tissue Specimens,Four lung adenocarcinoma cancer cell lines (SPCA1, H1299, PC-9,and H358), and normal human bronchial epithelial cell (16HBE) |
| Expression Pattern | up-regulated |
| Function Description | SNHG14 was remarkably higher-expressed in lung adenocarcinoma tissues than in adjacent samples. Moreover, cell proliferation and invasion of lung adenocarcinoma were promoted via overexpression of SNHG14, while cell proliferation and invasion of lung adenocarcinoma were inhibited via silence of SNHG14. Moreover, RT-qPCR results revealed that miR-613 was downregulated via overexpression of SNHG14, while miR-613 was upregulated via knockdown of SNHG14. |
| Pubmed ID | 31858549 |
| Year | 2019 |
| Title | Long Noncoding RNA SNHG14 Exerts Oncogenic Functions in Lung Adenocarcinoma Through Acting as a Sponge to miR-613 |
External Links
| Links for SNHG14 | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |