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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	pancreatic ductal adenocarcinoma
ICD-0-3	C25.3
Methods	RT-qPCR, Western blot analysis, RIP
Sample	pancreatic cancer tissues,PDAC cell lines Panc1, Panc28, 75 AsPC1 and BxPC3 and a human pancreatic ductal ep- 76 ithelial cell line HPDE
Expression Pattern	up-regulated
Function Description	SNHG14 expression was higher in PDAC tissue compared to adjacent normal tissues by qRT-PCR analysis. Higher SNHG14 expression was significantly associated with advanced TNM stage and positive lymph node metastasis in PDAC patients. Furthermore, we demonstrated that higher SNHG14 expression acted as a poor predictor in PDAC patients compared with lower SNHG14 expression. Moreover, we showed that higher SNHG14 expression promoted cell proliferation, cell colony formation and cell invasion ability in PDAC. Upregulation of SNHG14 expression promoted cell invasion by affecting E-cadherin expression via interacting with EZH2.
Pubmed ID	31929143
Year	2020
Title	Downregulation of Long Noncoding RNA SNHG14 Suppresses Cell Proliferation and Invasion by Regulating EZH2 in Pancreatic Ductal Adenocarcinoma (PDAC)

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