Basic Information
| LncRNA/CircRNA Name | BX647187 |
| Synonyms | NA |
| Region | GRCh38_3:111096428-111098928 |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR, RNAi, Western blot, Northern blot etc. |
| Sample | prostate cancer tissues, cell lines (LNCaP, PC3, Du145) |
| Expression Pattern | differential expression |
| Function Description | Our results showed that Hec1 mRNA and protein were significantly overexpressed in Human PCa tissues and several PCa cell lines. Silencing Hec1 markedly suppressed proliferation, promoted apoptosis and induced cell-cycle arrest in G2/M-phase in PCa cells. Through bioinformatics analysis and knockdown Hec1 in PCa cells, we found LncRNA BX647187 was positively regulated by Hec1. We further demonstrated that suppression of BX647187 in PCa cells significantly reduced cell proliferation and promoted apoptosis. |
| Pubmed ID | 26612002 |
| Year | 2015 |
| Title | The mitotic regulator Hec1 is a critical modulator of prostate cancer through the long non-coding RNA BX647187 in vitro. |
External Links
| Links for BX647187 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |