Basic Information
LncRNA/CircRNA Name | SNHG12 |
Synonyms | SNHG12, ASLNC04080, C1orf79, LINC00100, NCRNA00100, PNAS-123 |
Region | GRCh38_1:28578538-28582983 |
Ensemble | ENSG00000197989 |
Refseq | NR_024127 |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | Drug | |||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | non small cell lung cancer |
ICD-0-3 | C34 |
Methods | qPCR, Western blot |
Sample | NSCLiver Cancer tissue, NSCLiver Cancer cell line (A549 )and DDP-resistant cell line A549/DDP |
Expression Pattern | up-regulated |
Function Description | Overall, our study is the first to identify a SNHG12-miR-181a-MAPK/Slug axis to elucidate in part how SNHG12 exert functions in NSCLC MDR, providing a novel therapeutic target to overcome MDR in NSCLC. |
Pubmed ID | 29137407 |
Year | 2017 |
Title | LncRNA SNHG12 contributes to multidrug resistance through activating the MAPK/Slug pathway by sponging miR-181a in non-small cell lung cancer. |
External Links
Links for SNHG12 | GenBank HGNC NONCODE |
Links for non small cell lung cancer | OMIM COSMIC |