Basic Information
| LncRNA/CircRNA Name | SNHG12 |
| Synonyms | NA |
| Region | GRCh38_1:28578538-28582983 |
| Ensemble | ENSG00000197989 |
| Refseq | NR_024127 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay |
| Sample | human thyroid epithelial cell line (Nthy-ori 3-1, NTHY), papillary thyroid carcinoma cell lines (NPA87(Catalog No: SCSP-1635), B-CPAP (Catalog No: SCSP-543) and TPC-1(Catalog No: SCSP-791)), PTC tissues and corresponding noncancerous thyroid tissues |
| Expression Pattern | up-regulated |
| Function Description | SNHG12 was found to be increased in PTC tissues and cell lines using quantitative real-time PCR. Knockdown of SNHG12 significantly inhibited PTC cell proliferation, migration and invasion and induced apoptosis in vitro. Mechanistic investigations revealed that SNHG12 functions as a competing endogenous RNA (ceRNA) to sponge miR-16-5p, which was downregulated in PTC tissues. In addition, rescue assays further confirmed that SNHG12 contributed to the progression of PTC through regulating miR-16-5p expression. |
| Pubmed ID | 31355416 |
| Year | 2019 |
| Title | Long noncoding RNA small nucleolar RNA host gene 12 promotes papillary thyroid carcinoma cell growth and invasion by targeting miR-16-5p |
External Links
| Links for SNHG12 | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |