Basic Information
| LncRNA/CircRNA Name | SNHG12 |
| Synonyms | NA |
| Region | GRCh38_1:28578538-28582983 |
| Ensemble | ENSG00000197989 |
| Refseq | NR_024127 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay |
| Sample | glioma tissues, cell lines (U87, SHG44, A172, U251, NHA) |
| Expression Pattern | up-regulated |
| Function Description | SNHG12 expression was enhanced and high-expressed in the glioma clinical tissue samples and cell lines, knockdown of SNHG12 impaired the proliferation, induced the apoptosis in vitro. it was found that SNHG12 harbored the complementary binding sites with miR-101-3p at 3'-UTR, acting as a miRNA sponge. |
| Pubmed ID | 30098431 |
| Year | 2018 |
| Title | Long noncoding RNA SNHG12 facilitates the tumorigenesis of glioma through miR-101-3p/FOXP1 axis. |
External Links
| Links for SNHG12 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |